A recent study has found a link between low testosterone levels in men and an increased risk of death from all causes, including heart disease and stroke. The study, published in the Annals of Internal Medicine, suggests that normal testosterone levels may not be the primary factor in why men are more prone to heart attacks and strokes than women.

Testosterone, a crucial male sex hormone, plays a vital role in regulating various bodily functions, including bone mass, muscle mass, and libido. Produced in the testicles, it’s essential for sperm and red blood cell production.

The study analyzed data from over 24,000 men aged 50-76, with a minimum of five years of follow-up. Researchers found that men with testosterone levels below 213 ng/dL had a higher risk of death from any cause, with a 40% increased risk compared to those with normal testosterone levels. Below 153 ng/dL, the risk of heart disease-related death increased, with a nearly 60% higher risk compared to those with normal levels.

Experts note that few men will reach these very low concentrations where the risk of early death becomes significantly higher. The study suggests that low testosterone may contribute to health problems or indicate underlying health risks, and that testosterone impacts muscle, fat, and bone density, making low levels a potential risk factor or consequence of other health issues.

“For men who do have low levels of testosterone, they’re often going to be just a little low. A prevailing wisdom for decades has been that testosterone is the cause of increased strokes and heart attacks.
“These findings suggest that having either a baseline normal blood testosterone or testosterone therapy that raises blood testosterone into the normal range will not increase the risk of major adverse cardiac events,”

According to Dr. Anawalt, who was not part of the study, taking testosterone supplements is unlikely to prolong life for most men with low testosterone levels. However, he also notes that such supplements will likely not increase the risk of death either.

“A secondary study found that very low estradiol levels were linked to an increased risk of death in men. This is important because aromatase inhibitors, which are medications used to treat low testosterone in men, also reduce estradiol levels.
“Part of the benefit of testosterone in men is caused by its conversion to estradiol or estrogen. These results indicate that taking medications to block this conversion is not a good idea.
“Men need normal amounts of estrogen for good health. If you don’t have enough estrogen, a man’s body fat goes up and bone density and bone strength go down, ” Anawalt mentioned.

Dr. Yeap emphasized that further research is necessary to fully comprehend the relationship between testosterone and men’s health outcomes. In the meantime, he advised adopting simple healthy habits to support hormonal balance, such as a balanced diet and regular physical activity.

He further recommended.
“Men should be encouraged to take a greater interest in their health. And they should have health checks, and seek medical attention if symptoms, such as low sex drive and erectile dysfunction may be present.”